NIR-emissive Alkynylplatinum(II) Terpyridyl Complex as a turn-on selective probe for heparin quantification by induced helical self-assembly behaviour

The extent of self-assembly viametal–metal and π-π stacking interactions, induced by the polyanionic biopolymers, enables the class of alkynylplatinum(II) terpyridyl complexes to be applicable for the sensing of important biomacromolecules through the monitoring of spectral changes. Strong demand arises for the design of selective and practical detection techniques for the quantification of heparin, a highly negative-charged polysaccharidethat can function as anticoagulant, due to the prevention of hemorrhagic complications upon overdose usage.Aconvenient sensing protocol for the detection of UFH and LMWH, two common forms of heparins in clinical use, in buffer and biological medium has been demonstrated with the spectral changes associated with the induced self-assembly of a NIR-emissive platinum(II) complex. The detection range has been demonstrated to cover clinical dosage levels and the structurally similar analogues can be effectively differentiated based on their anionic charge density and the formation of supramolecular helical assembly of the platinum(II) complex with them ...postprin

Design of luminescent sulfur-containing polynuclear gold(I) complexes for advanced nanomaterials and chemosensors

A series of high-nuclearity gold(I) sulfido complexes with bridging diphosphine ligands have been synthesized and isolated, with the general formulae of [Au10(μ-P∧P)4(μ3-S) 4]X2 and [Au12(μ-P∧P) 6(μ3-S)4]X4 (P∧P = diphosphine; X = PF6 or ClO4). Intense green and orange emissions were observed upon excitation at λ > 350 nm both in the solid state and in solutions. The green emission has been attributed to originate from excited states derived from the metal-perturbed intraligand (IL) transition while the orange emission arises from the ligand-to-metal-metal bond charge-transfer (LMMCT; S (Au⋯Au) states. The switching on and off of the LMMCT emission in a series of dinuclear gold(I) thiolate complexes with crown ether pendants induced by ion-binding has been demonstrated, and this provides a new strategy for the design of luminescence signalling and chemosensing devices in optoelectronics and sensor technology.published_or_final_versio

Induced self-assembly and Förster Resonance Energy Transfer Studies of Alkynylplatinum(II) Terpyridine Complex through interaction with water-soluble Poly(phenylene ethynylene sulfonate) and the proof-of-principle demonstration of this two-component ensemble for selective label-free detection of Human Serum Albumin (HSA)

The interaction of conjugated polyelectrolyte, PPE-SO3−, with platinum(II) complexes, [Pt(tpy)(C≡CC6H4CH2NMe3-4)](OTf)2 (1) and [Pt(tpy)(C≡C–CH2NMe3)](OTf)2 (2), has been studied by UV–vis, and steady-state and time-resolved emission spectroscopy. A unique FRET from PPE-SO3−to the aggregated complex 1on the polymer chain with PtfflfflfflPt interactionhas been demonstrated, resulting in the growth of triplet metal-metal-to-ligand charge transfer (3MMLCT) emission ...postprin

Induced self-assembly and Förster resonance energy transfer studies of alkynylplatinum(II) terpyridine complex through interaction with water-soluble poly(phenylene ethynylene sulfonate) and the proof-of-principle demonstration of this two-component ensemble for selective label-free detection of human serum albumin

The interaction of conjugated polyelectrolyte, PPE-SO3 -, with platinum(II) complexes, [Pt(tpy)(C≡CC6H 4-CH2NMe3-4)](OTf)2 (1) and [Pt(tpy)(C≡C-CH2NMe3)]-(OTf)2 (2), has been studied by UV-vis, and steady-state and time-resolved emission spectroscopy. A unique FRET from PPE-SO3 - to the aggregated complex 1 on the polymer chain with Pt···Pt interaction has been demonstrated, resulting in the growth of triplet metal-metal-to-ligand charge transfer (3MMLCT) emission in the near-infrared (NIR) region. This two-component ensemble has been employed in a "proof-ofprinciple" concept for the sensitive and selective label-free detection of human serum albumin (HSA) by the emission spectral changes in the visible and in the NIR region. The spectral changes have been ascribed to the disassembly of the polymer-metal complex aggregates upon the binding of PPE-SO3 - to HSA, which is rich in arginine residues and hydrophobic patches, leading to the decrease in FRET from PPE-SO 3 - to the aggregated platinum(II) complex. The ensemble is found to have high selectivity toward HSA over a number of polyelectrolytes, proteins and small amino acids. This has been suggested to be a result of the extra stabilization gained from the Pt··· Pt and π-π interactions in addition to the electrostatic and hydrophobic interactions found in the polymer-metal complex aggregates. © 2011 American Chemical Society.link_to_subscribed_fulltex

Material Selection for Donor Materials in Small Molecular-Based Bulk Heterojunction Organic Photovoltaic Devices

Poster Presentation: S15- Metal Complexes for Optics: from fundamental to applications: no. S15.P23published_or_final_versio

Parallel Folding Topology-Selective Label-Free Detection and Monitoring of Conformational and Topological Changes of Different G-Quadruplex DNAs by Emission Spectral Changes via FRET of mPPE-Ala–Pt(II) Complex Ensemble

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Anion Binding Properties of Alkynylplatinum(II) Complexes with Amide-Functionalized Terpyridine: Host-Guest Interactions and Fluoride Ion-Induced Deprotonation

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Luminescence enhancement in dinuclear alkynylplatinum(II) complexes driven by Hierarchical Assembly through Pt···Pt and π-π stacking interactions

Poster: no. 1A luminescent dinuclear alkynylplatinum(II) complex containing an amphiphilic binaphthol bridge was designed and synthesized, and was shown to display cylindrical columnar assemblies in aqueous acetonitrile solutions, presumably mediated by the Pt•••Pt and π-π stacking interactions. The length of the binaphthol bridge was found to have a profound effect on the degree of helicity for hierarchical helices of helices and serves as a critical determinant in the formation of tertiary structures for foldamers. Interestingly, the reciprocal association of multiple helices has led to luminescence enhancement behavior, which provides a luminescence turn-on switch for the reporting of the hierarchical assembly of foldamers into higher-order structures, distinct from that of the pure organic systems. Such a transverse aggregation of multiple helices driven by metallophilic interactions has been studied by electronic absorption, circular dichroism, emission spectroscopy and electron microscopy.published_or_final_versio

Amphiphilic Anionic Pt(II) Complexes: from spectroscopic to morphological changes

A new class of amphiphilic anionic platinum(II) bzimpy complexes has been demonstrated to show aggregation in water through PtfflfflfflPt and π–π stacking interactions. An interesting aggregation–partial deaggregation–aggregation process and a morphological transformation from vesicles to nanofibers have been demonstrated. These changes can be systematically controlled by the variation of solvent composition and could readily be probed by UV-vis absorption, emission, NMR, transmission electron microscopy and even with our naked eyes ...postprin